Trans-resveratrol powder is a high-purity, crystalline form of a polyphenol found in plants like red grapes and Japanese knotweed. It is the biologically active isomer of resveratrol, preferred in supplements over the "cis" form because it is more stable and more effectively absorbed by the body.
Technical Specifications
-
CAS Number: 501-36-0
-
Chemical Formula:
-
Molecular Weight: 228.24 g/mol.
-
Appearance: Typically a white to off-white or light yellow powder.
-
Solubility: Low in water (g/L) but highly soluble in ethanol or DMSO.
Core Health and Skincare Benefits
Trans-resveratrol is widely researched for its potent antioxidant and anti-inflammatory properties.
-
Longevity & Anti-Ageing: It is believed to activate sirtuins (like SIRT1), proteins that regulate cellular health and mimic the effects of caloric restriction.
-
Cardiovascular Support: Research suggests it may help lower blood pressure, reduce "bad" LDL cholesterol, and improve blood vessel function.
-
Skincare: When applied topically (often in concentrations up to 3%), it neutralises free radicals, protects against UV-induced damage, and can stimulate collagen production to reduce wrinkles.
-
Neuroprotection: It may support brain health by protecting neurons from oxidative stress and preserving memory.
Dosage and Usage Tips
-
Typical Dose: Dietary supplements generally range from 250mg to 1,500mg per day.
-
Absorption Hack: Trans-resveratrol has poor bioavailability on its own. It is best taken with a fat-containing meal (like yogurt or avocado) to aid absorption.
-
Formulations: Look for "micronised" powders, which have a smaller particle size for better mixability and higher bioavailability.
Safety and Precautions
While generally well-tolerated at moderate doses, some risks exist:
-
Gastrointestinal Issues: Doses exceeding 1,000mg to 2,500mg daily may cause nausea, cramping, or diarrhoea.
-
Hormone Sensitivity: Because it can mimic estrogen, it should be avoided by individuals with hormone-sensitive conditions like endometriosis or certain cancers.
-
Blood Thinning: It can slow blood clotting. Stop use at least two weeks before surgery and consult a doctor if taking blood thinners like Warfarin or Ibuprofen.
-
Drug Interactions: High doses can inhibit certain liver enzymes, potentially causing other medications (like some blood pressure or anxiety meds) to build up to unsafe levels.
